UBC researcher finds new way to treat devastating fungal infections Pharmaceutical Sciences Prof. Kishor M. Wasan has created a liquid preparation that incorporates drug molecules in fat (lipid-based formulation) so that Amphotericin B, a potent anti-fungal agent, can be taken by mouth with minimal side effects. The agent, used for about 50 years, is currently administered intravenously and has significant toxic side effects, notably severe kidney toxicity as well as serious tissue damage at the intravenous injection site.
Surveillance of the prevalence of Leishmania and its vector, sand fly species, in endemic and surrounding areas is important for prediction of the risk and expansion of leishmaniasis. In this study, a method for the mass screening of sand flies for Leishmania infection was established.
Merlin Clark Leishmaniasis went undiagnosed or undisclosed at Walter Reed and attacked the reconstruction of his leg.
Zachary Tyler returned to Richmond, Va., after he contracted a parasitic disease called leishmaniasis from sandfly bites. "It really gives us a sense of encouragement
For natural alternatives to toxic treatments for vector borne skin diseases please check out
Parasite Payback Leishmania might be vulnerable to a common anticancer drug The breast cancer drug tamoxifen kills the single-celled parasite known as leishmania, a scourge common in the tropics, Brazilian scientists report. While the tests in mice are preliminary, the finding is heartening because few good treatments for leishmaniasis exist, says Silvia Uliana, a physician at the University of São Paulo.
Compared to the other drug treatments, the rats on amphotericin B had the highest blood levels and lowest kidney levels of the drug, indicating that the body more readily absorbed amphotericin B than any other drug. What's more, oral amphotericin B seemed to bypass the renal toxicity normally associated with intravenous forms of the drug (