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UBC researcher finds new way to treat
devastating fungal infections
Pharmaceutical Sciences Prof. Kishor M.
Wasan has created a liquid preparation that
incorporates drug molecules in fat
(lipid-based formulation) so that
Amphotericin B, a potent anti-fungal agent,
can be taken by mouth with minimal side
effects. The agent, used for about 50 years,
is currently administered intravenously and
has significant toxic side effects, notably
severe kidney toxicity as well as serious
tissue damage at the intravenous injection
site.
devastating fungal infections
Pharmaceutical Sciences Prof. Kishor M.
Wasan has created a liquid preparation that
incorporates drug molecules in fat
(lipid-based formulation) so that
Amphotericin B, a potent anti-fungal agent,
can be taken by mouth with minimal side
effects. The agent, used for about 50 years,
is currently administered intravenously and
has significant toxic side effects, notably
severe kidney toxicity as well as serious
tissue damage at the intravenous injection
site.
Effect of topical honey application along
with intralesional injection of glucantime in
the treatment of cutaneous leishmaniasis
Topical application of honey has been shown to
be effective in treatment of the post-operative
wound infections, reducing the need for
antibiotics and finally reducing remaining scar
with intralesional injection of glucantime in
the treatment of cutaneous leishmaniasis
Topical application of honey has been shown to
be effective in treatment of the post-operative
wound infections, reducing the need for
antibiotics and finally reducing remaining scar
Establishment of a Mass Screening
Method of Sand Fly Vectors for
Leishmania Infection by Molecular
Biological Methods
Surveillance of the prevalence of Leishmania
and its vector, sand fly species, in endemic
and surrounding areas is important for
prediction of the risk and expansion of
leishmaniasis. In this study, a method for the
mass screening of sand flies for Leishmania
infection was established.
Method of Sand Fly Vectors for
Leishmania Infection by Molecular
Biological Methods
Surveillance of the prevalence of Leishmania
and its vector, sand fly species, in endemic
and surrounding areas is important for
prediction of the risk and expansion of
leishmaniasis. In this study, a method for the
mass screening of sand flies for Leishmania
infection was established.
Leishmaniasis Casualties
Merlin Clark
Leishmaniasis went undiagnosed or
undisclosed at Walter Reed and
attacked the reconstruction of his
leg.
Zachary Tyler
returned to Richmond, Va., after he
contracted a parasitic disease
called leishmaniasis from sandfly
bites. "It really gives us a sense of
encouragement
Merlin Clark
Leishmaniasis went undiagnosed or
undisclosed at Walter Reed and
attacked the reconstruction of his
leg.
Zachary Tyler
returned to Richmond, Va., after he
contracted a parasitic disease
called leishmaniasis from sandfly
bites. "It really gives us a sense of
encouragement
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Parasite Payback
Leishmania might be vulnerable to a common
anticancer drug
The breast cancer drug tamoxifen kills the
single-celled parasite known as leishmania, a
scourge common in the tropics, Brazilian scientists
report. While the tests in mice are preliminary, the
finding is heartening because few good treatments
for leishmaniasis exist, says Silvia Uliana, a
physician at the University of São Paulo.
Leishmania might be vulnerable to a common
anticancer drug
The breast cancer drug tamoxifen kills the
single-celled parasite known as leishmania, a
scourge common in the tropics, Brazilian scientists
report. While the tests in mice are preliminary, the
finding is heartening because few good treatments
for leishmaniasis exist, says Silvia Uliana, a
physician at the University of São Paulo.
Anti Fungal Fight
Compared to the other drug treatments, the
rats on amphotericin B had the highest blood
levels and lowest kidney levels of the drug,
indicating that the body more readily absorbed
amphotericin B than any other drug. What's
more, oral amphotericin B seemed to bypass
the renal toxicity normally associated with
intravenous forms of the drug (
Compared to the other drug treatments, the
rats on amphotericin B had the highest blood
levels and lowest kidney levels of the drug,
indicating that the body more readily absorbed
amphotericin B than any other drug. What's
more, oral amphotericin B seemed to bypass
the renal toxicity normally associated with
intravenous forms of the drug (